Beilstein J. Org. Chem.2018,14, 2607–2617, doi:10.3762/bjoc.14.239
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Keywords: antimicrobial resistance; bacterialadhesins; bacterial toxins; pathoblockers; quorum sensing; Review
1. Antimicrobial resistance crisis for bacterial infections
The current crisis caused by antimicrobial resistance [1][2] demands new strategies to fight infections. Antibiotics have served as
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Graphical Abstract
Figure 1:
Mannosides as inhibitors of the lectin FimH from uropathogenic Escherichia coli.
Beilstein J. Org. Chem.2017,13, 2584–2595, doi:10.3762/bjoc.13.255
lectins and of three bacterialadhesins were analyzed. One important finding is that the high enthalpic penalties caused by desolvation can only be compensated for by the number and quality of hydrogen bonds formed by each of the polar hydroxy groups engaged in the binding process. In addition, since
lectins, the bacterialadhesins, play an important role in the initial interaction of the bacterium with host tissue [9][10]. This primary contact is a prerequisite for the infection of host cells and subsequent biofilm formation, and grants the bacteria a significant advantage by resisting clearance and
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Graphical Abstract
Figure 1:
CRDs of the analyzed crystal structures, with mannose pyranosyl units similarly aligned in each str...